Novartis

Novartis AG is a holding company, which engages in the development, manufacture, and marketing of healthcare products. It operates through the following segments: Innovative Medicines, Sandoz, and Corporate. The Innovative Medicines segment researches, develops, manufactures, distributes and sells patented pharmaceuticals, and is composed of two business units: Novartis Oncology and Novartis Pharmaceuticals. The Sandoz segment develops, manufactures and markets finished dosage form medicines as well as intermediary products, including active pharmaceutical ingredients. The Corporate segment refers to group management and central services. The company was founded on February 29, 1996 and is headquartered in Basel, Switzerland.

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Novartis AG is a holding company, which engages in the business of developing, manufacturing, and marketing healthcare products. It operates through the following segments: Innovative Medicines, Sandoz, and Corporate. The Innovative Medicines segment includes researching, distributing and selling patented pharmaceuticals. The Sandoz segment focuses on marketing finished dosage form medicines and intermediary products including active pharmaceutical ingredients. The Corporate segment is involved in group management and central services. The company was founded on February 29, 1996 and is headquartered in Basel, Switzerland.

ACTIV-3 trial planned to investigate safety and efficacy of ensovibep in adults hospitalized with a COVID-19 diagnosis; first patient dose expected in Q2 2021 Ensovibep to be first non-antibody therapeutic assessed in ACTIV-3 Clinical trial includes an interim analysis after 300 patients Separately, a global Phase 2-3 study in adults with mild to moderate symptoms is planned to be initiated in Q2 2021 Initial Phase 1 data support safety, tolerability and 2-3 week half-life of ensovibep ZURICH-SCHLIEREN, SWITZERLAND / ACCESSWIRE / March 15, 2021 / Molecular Partners AG (SIX:MOLN), a clinical-stage biotech company that is developing a new class of custom-built protein drugs known as DARPin® therapeutics, and its collaborator Novartis, today announced that ensovibep (formerly MP0420) is expected to be included in a global phase 3 randomized, controlled clinical trial as part of the National Institutes of Health's (NIH) Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV) program. The trial, ACTIV-3, is designed to evaluate the safety and efficacy of various therapies for the treatment of adults hospitalized with a COVID-19 diagnosis.

Molecular Partners and Novartis Announce Inclusion of COVID-19 Antiviral Candidate, ensovibep, in NIH-Sponsored ACTIV-3 Trial

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NLS Pharma (NLSP) stock is taking off on Friday after announcing an exclusive license agreement with Novartis (NVS) for mazindol data. The post NLSP Stock: The Big Deal News That Has NLS Pharma Rocketing Nearly 100% Today appeared first on InvestorPlace.

NLSP Stock: The Big Deal News That Has NLS Pharma Rocketing Nearly 100% Today

NLS Pharmaceutics AG (NASDAQ: NLSP) stock has more than doubled in reaction to a License Agreement with Novartis Pharma AG, a unit of Novartis AG (NYSE: NVS), wherein NLS secured an exclusive license to Sanorex (mazindol) in the U.S. Sandoz developed Sanorex as an immediate-release obesity drug designed to shed pounds fast.

NLS Pharmaceutics Stock Surges On Obesity Drug Licensing Pact With Novartis Pharma

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Novartis (NVS) pipeline candidate, canakinumab, fails to meet the primary endpoint in lung cancer study.

Novartis' (NVS) NSCLC Drug Fails to Meet Primary Endpoint

Novartis AG (NYSE: NVS) reported data from the Phase 3 CANOPY-2 study evaluating canakinumab (ACZ885) in advanced or metastatic non-small cell lung cancer (NSCLC). The study did not meet the primary endpoint of overall survival (OS).

Novartis' Canakinumab Fails To Improve Survival In Late-Stage Lung Cancer Trial

Molecular Partners AG (OTCMKTS: MLLCF) and its collaborator Novartis AG (NYSE: NVS) have announced initial results from the ongoing Phase 1 study of its COVID-19 antiviral treatment, ensovibep (MP0420), in healthy volunteers. In two cohorts of a single infusion of either 3mg or 9mg per kilogram body weight dosing, ensovibep was seen to be safe and well-tolerated.

Molecular Partners/Novartis's COVID-19 Antiviral Therapy Shows Encouraging Action Early-Stage Study

Initial findings show ensovibep to be safe and well tolerated with no significant adverse events Predictable exposure seen post administration, confirming the expected half-life of 2‑3 weeks Global phase 2/3 registrational study planned to initiate in Q2 2021 ZURICH-SCHLIEREN, SWITZERLAND / ACCESSWIRE /  March 9, 2021 / Molecular Partners AG (SWX: MOLN), a clinical-stage biotech company that is developing a new class of custom-built protein drugs known as DARPin® therapeutics, and its collaborator Novartis, today announced initial results from its ongoing phase 1 study of its first tri-specific COVID-19 antiviral treatment, ensovibep (MP0420), in healthy volunteers. In the placebo-controlled phase 1 study, healthy volunteers were randomized 3:1 to receive an infusion of ensovibep, or placebo, respectively.

Molecular Partners and Novartis Report Positive Initial Results from Phase 1 Study of its COVID-19 Antiviral Therapy, Ensovibep, in Healthy Volunteers

Basel, March 9, 2021 — Novartis announced today the Phase III CANOPY-2 study evaluating canakinumab (ACZ885), an inhibitor of interleukin-1beta (IL-1β), in combination with the chemotherapy agent docetaxel, did not meet its primary endpoint of overall survival (OS)1. The trial was conducted among 237 adults with locally advanced or metastatic non-small cell lung cancer (NSCLC) whose disease progressed while on or after previous platinum-based chemotherapy and PD-(L)1 inhibitor immunotherapy4 .  Two Phase III CANOPY trials continue, evaluating canakinumab in first-line and adjuvant settings2,3. Novartis and CANOPY-2 investigators will analyze the study data and are expected to submit its findings for presentation at an upcoming medical meeting.

Novartis provides update on Phase III study evaluating canakinumab (ACZ885) as second or third-line treatment in combination with chemotherapy in non-small cell lung cancer

CureVac B.V

Novartis (NVS) will manufacture the mRNA and bulk drug product for CureVac's COVID-19 vaccine candidate.

Novartis (NVS) & CureVac Collaborate for COVID-19 Vaccine

Basel, March 5, 2021 — Novartis announced today that Shannon Thyme Klinger, Chief Legal Officer, has decided to resign from Novartis and return to the US to take an executive role at a biotechnology company. Ms. Klinger will step down from the Executive Committee of Novartis (ECN), effective March 15, 2021.

Novartis announces change to the Executive Committee

Swiss Pharma giant Novartis AG (NYSE: NVS) has agreed to help CureVac BV (NASDAQ: CVAC) produce its experimental COVID-19 vaccine, known as CVnCoV. Novartis plans to manufacture the mRNA molecules that the vaccine is based on and “bulk drug product” for up to 50 million doses by the end of 2021 and up to a further 200 million doses in 2022.

Novartis Lends Support To Manufacture CureVac's COVID-19 Shots

Novartis AG and CureVac NV said Thursday they have reached an agreement for Novartis to help CureVac manufacture its COVID-19 vaccine, which is currently under review by the European Medicines Agency. Novartis expects to make up to 50 million doses of the vaccine by the end of 2021, and up to a further 200 million doses in 2022, at its manufacturing site in Kundl, Austria.

Novartis agrees to help make CureVac COVID-19 vaccine

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Homology Medicines

Homology Medicines Inc (NASDAQ: FIXX) has regained worldwide exclusive rights from Novartis AG (NYSE: NVS) to research, develop, manufacture, and commercialize its proprietary nuclease-free gene-editing technology platform for an ophthalmic target. Novartis had concluded the collaboration and licensing agreement with Homology announced in 2017 to pursue other opportunities in their pipeline.

Homology Medicines Regains Global Rights To Novartis Ophthalmology Program

making Novartis an even more interesting and timely stock to look at, is the fact that in trading on Tuesday, shares of NVS entered into oversold territory, changing hands as low as $86.472 per share.

Novartis Is Oversold

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Novartis is currently trading at a 6.75% free cash flow yield. The FCF is higher than the net income due to the amortization of intangibles.

Novartis Hikes Its Dividend Again, Now Yields 3.8%

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EAST HANOVER, N.J., Feb. 16, 2021 /PRNewswire/ -- Novartis today announced that the US Food and Drug Administration (FDA) has approved the following expanded indication for Entresto® (sacubitril/valsartan): to reduce the risk of cardiovascular death and hospitalization for heart failure...

Novartis Entresto® granted expanded indication in chronic heart failure by FDA

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Basel, February 11, 2021 – Sandoz, a Novartis division, has signed an agreement to acquire GSK's cephalosporin antibiotics business, reinforcing its leading global position in antibiotics.

Sandoz announces agreement to acquire GSK's cephalosporin antibiotics business, reinforcing its leading global position in antibiotics

Novartis' (NVS) asciminib gets Breakthrough Therapy tag by the FDA for the treatment of adult patients with Ph+ CML in chronic phase, previously treated with two or more tyrosine kinase inhibitors.

Novartis (NVS) Gets Breakthrough Therapy Tag for Leukemia Drug

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News for Novartis Stock (NVS)